The Mail For Exchange client on the E52 is similar in terms of functionality and the setup procedure to the E75. To add a new email account to the phone, open the menu from the home screen and select Email:

The following screen will be displayed:

Select New, the email wizard will be displayed:

Click Start, the wizard will require access to the Internet in order to be able to attempt to determine account settings automatically and you will be prompted to select an access point to use:

Select the access point, you will be prompted to enter your email address:

and password:

you may also be prompted again to select an access point to allow the wizard to connect to the Internet:

You will then be prompted to confirm what sort of email account you wish to configure:

Select Mail For Exchange. You will then be prompted for your username (this will be your Windows username, the same that you use to log into your PC if you have one):

You will then be prompted to enter a Domain:

Again this will usually be the same information that you use to log into your PC: when logging into Windows you usually enter a username, password and also have a 'log into' field - it is the contents of this field that needs to be entered.
You will then be prompted to enter the address of the Exchange Server:

This will be the same address used to access Outlook Web Access, or webmail, usually in the form 'mail.domain.com'. Once all of this information has been entered the wizard will be completed:

The Mail For Exchange client will then launch and again prompt you to confirm that the application should have access to the Internet:

You can stop this confirmation message from being displayed by selecting the option to 'Accept and set use access point to automatically'.
The contents of your email Inbox will now be downloaded automatically. By default only your email will be set to synchronise: contacts, calendar and tasks folders must be enabled manually.
Return to the Email menu and select Settings:

Select Personal Information Manager:

Select Applications:

The following screen will be displayed:

Contacts, Calendar and Tasks folders can be enabled for synchronisation as required:

Once synchronisation has completed (depending on the amount of contacts, calendar and mail items you have to be synchronised this process can take up to a few minutes before information is available), you will be able to browse your email folders and subfolders:

To edit settings once the initial setup has completed, select the Settings option from the menu within the Email application:

The Mailbox settings view allows you to edit your mail server and login details:

The What to sync view allows you to specify how far back into the past you wish to synchronise - note that this setting will be applied to all folders, including subfolders, therefore don't be surprised if some folders appear empty even though there is mail in them:

The When to sync view allows you to specify between which hours synchronisation will be push-based, and outside of those hours how synchronisation should be handled (ie manually or on a schedule):

The Global Settings view allows you to define display options:

The Exchange GAL (Global Address List), or company address book, can be accessed from the Email screen:

Certificates

If your Exchange server uses a self-issued, or 'non root-trusted' SSL certificate, then the corresponding root certificate of the CA (Certification Authority) that issued the certificate to the Exchange server will need to be installed onto the E52 manually before the phone will be able to connect to the Exchange server.
If you don't know whether your Exchange server is using a self-issued certificate or not, one way to check is to browse to the server's webmail address (normally in the form 'https://mail.domain.com') - if you receive a warning before being presented with the login screen along the lines of 'the security certificate used by this web site cannot be verified, do you want to continue anyway?', then the server's certificate is not root-trusted.

To install the certificate onto the phone, it will need to be exported from the CA first in '.DER' format, read this article for more information - http://blog.brightpointuk.co.uk/configuring-exchange-2003-activesync-usi...

Once you have the certificate file, it can be copied onto the phone either by connecting it to a PC via USB, or by downloading it via the browser from a suitable web server. This process is detailed in my guide on setting up the E71 - http://blog.brightpointuk.co.uk/setting-mail-exchange-nokia-e71